My answer:
Heartworms actually are mostly located in the pulmonary arteries, the blood vessels that take blood from the right side of the heart to the lungs to get oxygen. Their presence in these tubes interferes with the circulation in the lungs, and makes the arteries themselves inflamed. This can cause swelling, which narrows the opening in the artery, further interfering with this blood circulation.
Even when there are no worms in the heart yet, this difficulty in the lung blood vessels makes it more difficult for the heart to do its work. This causes excessive wear and tear on the heart.
Doxycycline inhibits a microorganism called Wohlbachia that benefits the heartworms (much as the "good" bacteria in our intestines help us). When the dog takes doxycycline, the heartworms become weaker and physically smaller. Thus, they cause less interference with the dog's circulation. Doxycycline is also a little bit of an anti-inflammatory medicine.
Prednisone is a form of cortisone, which is a potent anti-inflammatory medicine. If the worms are causing swelling of the blood vessels (making the opening smaller, and more difficult for the heart to work against), the prednisone can open things up again.
There is currently a severe shortage of Immiticide, the drug used to kill adult heartworms. Until it becomes available again, the American Heartworm Society is recommending that dogs be managed in the way that your veterinarian is recommending.
I think that your veterinarian's recommendations are very reasonable, considering your circumstances. If you have more questions, please take the time to let him/her know. Many times we think that we are great communicators. If nobody calls back, we just assume all their questions have been answered. If you have more questions, I'll bet that your veterinarian will be happy to discuss them with you.
A reader writes in today:
Had our cocker spaniel treated 5 hours ago with his first shot.
For the past 5 hours, he can not get comfortable, fidgets, lays in unusual positions.
When walking, his right rear leg is toeing-in and his walks clumsily, often positioning that right foot too far under his body.
In just the last hour, he has started some toe-dragging with that right foot. Not severe, and he corrects upon moving further into the stepping process.
Also, he has started to drool excessively. Both ears are wet as if he drank from a flat bowl.
Have given him 2.5 mg Diazepam to try to make him more comfortable.
Forgot to mention ... the vet had to stick him twice unsuccessfully and then changed needles and successfully administered on the third try.
Do you think he is just experiencing more pain than usual because of the three 'sticks' at the site, or should we be concerned that something else is going on?